Aaron A. King, Ph.D.

Nelson G. Hairston Collegiate Professor of
Ecology & Evolutionary Biology, Complex Systems, and Mathematics
University of Michigan

Epidemiological evidence for herd immunity induced by acellular pertussis vaccines

M. Domenech de Cellès, M. A. Riolo, F. M. G. Magpantay, P. Rohani, and A. A. King
Proceedings of the National Academy of Sciences of the U.S.A. 111(7): E716–E717, 2014.

In a series of elegant experiments on baboons, Warfel et al. conclude that acellular pertussis vaccines (aP) prevent disease but fail to protect against transmissible infection. The authors speculate that this fact may explain the resurgence of pertussis in some countries. Although the animal model of Warfel et al. is a true breakthrough, we question the soundness of their extrapolation to transmission in human populations. Indeed, much available epidemiological evidence argues against it.


The official version of the paper is here.   Please contact Prof. King if you'd like a reprint.

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