Aaron A. King, Ph.D.

Nelson G. Hairston Collegiate Professor of
Ecology & Evolutionary Biology, Complex Systems, and Mathematics
University of Michigan

Maternal pertussis immunisation: clinical gains and epidemiological legacy

A. I. Bento, A. A. King, and P. Rohani
Eurosurveillance 22(15): 3, 2017.

The increase in whooping cough (pertussis) incidence in many countries with high routine vaccination coverage is alarming, with incidence in the US reaching almost 50,000 reported cases per year, reflecting incidence levels not seen since the 1950s. While the potential explanations for this resurgence remain debated, we face an urgent need to protect newborns, especially during the time window between birth and the first routine vaccination dose. Maternal immunisation has been proposed as an effective strategy for protecting neonates, who are at higher risk of severe pertussis disease and mortality. However, if maternally derived antibodies adversely affect the immunogenicity of the routine schedule, through blunting effects, we may observe a gradual degradation of herd immunity. ‘Wasted’ vaccines would result in an accumulation of susceptible children in the population, specifically leading to an overall increase in incidence in older age groups. In this Perspective, we discuss potential long-term epidemiological effects of maternal immunisation, as determined by possible immune interference outcomes.


The official version of the paper is here.   Please contact Prof. King if you'd like a reprint.

© 2019 Aaron A. King
3068 Biological Sciences Building
1105 North University Avenue
Ann Arbor MI 48109-1085 USA