In this Challenge, you are asked to design a drug dose schedule.
Suppose you need to ensure that your patient maintains a blood concentration of at least 0.2 μg/ml. The drug is administered in time-release capsule form such that, each hour, 20% of the remaining drug is released. The drug is cleared by the patient’s liver at a rate of 30% per hour. Severe liver damage can ensue if the concentration ever exceeds 0.3 μg/ml. Assume that your patient has a blood volume of 5 l. Find a dose size and schedule that meets the requirements with the lowest possible dose frequency.
.Rmd
and .pdf
files. It may be easiest to generate an .html
file first and then use a browser to print to a PDF document.An Rmarkdown template is provided to help you get started.
Important Note: You will turn in each draft of your report via the course Canvas site. Upload both the Rmarkdown document and a PDF version of your report. Choose the filenames according to the following formula: Challenge_X-Y.Z
where X
is the challenge problem number (here, 2), Y
is the draft number (1, 2, or 3), and Z
is the appropriate extension (.Rmd
or .pdf
).